Potential pathway for emergence of zoonotic malaria identified

first_img Read Full Story The parasite responsible for a form of malaria now spreading from macaques to humans in South Asia could evolve to infect humans more efficiently, a step towards enhanced transmission between humans, according to a new study from Harvard T.H. Chan School of Public Health. The researchers say that defining the means by which the Plasmodium knowlesi parasite invades red blood cells could lead to interventions to prevent emergence of the zoonosis into the human population.The researchers identified a sugar variant on the surface of human red blood cells that currently limits the ability of P. knowlesi to invade, and demonstrated that the monkey malaria parasite has the ability to evolve to get around this barrier and pass into the human population in a more virulent form.The study will appear online April 4, 2016 in Nature Communications.“With increasing concern about the spread of P. knowlesi into human populations, it is great to be able to gain insight into what the molecular stumbling blocks are for P. knowlesi infection of humans, and how the parasite can potentially overcome them,” said first author Selasi Dankwa, who carried out the work while a doctoral student in the Department of Immunology and Infectious Diseases at the Harvard Chan School.The macaque malaria parasite P. knowlesi has emerged as a major source of human infections in Southeast Asia, as the monkey’s habitats are encroached upon through logging and farming. While most human infections are mild, increasing numbers of severe infections are being reported.last_img read more

Daily Dirt: March 21, 2013

first_imgYour outdoor news for March 21, 2013:New Routes Go Up in the New River GorgeIn a great post on DPM Climbing, Mike Williams reports that new trad routes are going up in the New River Gorge. Focusing on popular Thunder Buttress of Beauty Mountain, Williams tells the tale of how Pat Goodman claimed the first ascent of Gun Control, a variation off of the established Gun Club. It’s great to see new things being done in a place like the New, where folks have been climbing since the 80’s; refreshing to know that there still remains undiscovered and unconquered territory out there. One of the things I love about climbing pieces is the names of the routes. Some highlights from this post are: The Thundering Herd, The Golden Bullet, In Gold Blood, and That’s What She Said. I also love stories written by climbers for all the climbing jargon and especially this one because it tells the story of a first ascent through the history of the place and the lives of the people who climb it.Snowboarding Industry SummitSo reports from this winter indicate that the snowboard industry is in decline, while the ski industry is ticking up, meaning that young peoples in general are picking up skiing and sticking with it longer than snowboarding. When those in the industry learned this, some flew off the handle, but most took the news calmly enough even if they were tearing out their eyeballs in private about the death of snowboarding AS WE KNOW IT! A decline in snowboarding interest is especially important on the East Coast where the sport has traditionally been as popular – if not more popular- than skiing because it was cool and different. But now that the two styles/attitudes/punks have leaked into each discipline, the lines are blurred and snowboarding is losing out. The leaders of the industry met in Deer Valley last week at the TransWorld Conference to hash out what the sport has to do to keep growing and stop retracting. This was no emergency Situation Room type of thing – it happens every year – but the emphasis this year was definitely on the sport as a whole and not just the brands behind the curtain. We’ll see what the big players come up with next season to reflect this trend. This past season we saw Burton launch a huge “Learn to Ride” program for the kids, so expect more of that. Get ’em hooked young.You can read the full recap of the conference here.Public Support for Keystone WaningAccording to a new poll for the Center of Biological Diversity by Public Policy Polling, 61 percent of those who voted for President Obama in the last election would be “disappointed” or “betrayed” if he goes ahead with the Keystone XL Pipeline. Almost 75 percent of the general public thought the Keystone XL is not in the U.S.’s “best interest.” Plenty more numbers in this story from the Sierra Club.last_img read more

Setauket Man’s Killer Pleads Guilty

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York An ex-fugitive has admitted to fatally shooting a 50-year-old Setauket man who was a well-known equestrian and wounding another victim last year before leading authorities on a cross-country manhunt.Brett Knight pleaded guilty Wednesday at Suffolk County court to second-degree murder, attempted murder, harassment and criminal possession of a weapon.Authorities have said that the 46-year-old gunned down Ross Reisner and seriously wounded Kevin Murray after firing gunshots through the window of Reisner’s Upper Sheep Pasture Road home at 8:45 p.m. on Sept. 24, 2013.Two handguns were recovered from the scene, authorities said at the time.Knight fled Long Island after the shooting on a motorcycle, but federal investigators apprehended him a month later in Seymour, Tenn., which is just south of Knoxville.He will be sentenced Feb. 4 by Judge Richard Ambro.last_img read more